Endocrine Abstracts

Background: Several ultrasound (US) scoring systems have been proposed to provide rules for standardizing risk stratification of thyroid nodules and to select which nodules should have a fine needle aspiration (FNA) biopsy performed. TI-RADS classification is one of the most used in the daily practise. Recently, EU-TIRADS scoring system has been published to simplify the evaluation of thyroid nodules and to integrate previous classifications into a single system. We aimed to c...

Aims: Spain has been one of the worst affected countries by the COVID-19 pandemic. A very strict lockdown at home was imposed with a tough restriction of mobility. We aimed to evaluate the impact of this exceptional scenario on glucose profile of patients with type 1 diabetes (T1D) prone to hypoglycemia using sensor-augmented pump (SAP).Methods: Patients with T1D prone to hypoglycemia using SAP (640G Medtronic Minimed) for at least 6 months under the fun...

Aims: Spain has been one of the worst affected countries by the COVID-19 pandemic. A very strict lockdown at home was imposed with a tough restriction of mobility. We aimed to evaluate the impact of this exceptional scenario on glucose profile of patients with type 1 diabetes (T1D) prone to hypoglycemia using standalone continuous glucose monitoring.Methods: Patients with T1D prone to hypoglycemia using multiple daily injections and either a Dexcom G5 or...

Introduction: Constitutional thinness (CT) is a rare condition of natural low body weight, with normal menstruation, no fear of weight gain and no hormonal abnormalities except for an anorexigenic hormonal profile. CT can be considered as the opposite of obesity and its resistance to weight loss. Therefore, we hypothesised they would have a resistance to weight gain.Methods: 10 female Controls (BMI 18.5–25 kg/m2) and 10 CT women (BMI<...

Introduction: Smokers around the globe commonly report increased body weight after smoking cessation as a major factor that interferes with their attempts to quit. In addition, numerous controlled studies in both humans and rodents have reported that nicotine exerts a marked anorectic action. Nicotine’s effects on energy homeostasis have been mostly pinpointed in the central nervous system, but the molecular mechanisms controlling its action are still not fully understood...

Introduction: Although involved in feeding and weight homeostasis, stimulation of pituitary GH secretion is the best established action of stomach-produced hormone ghrelin. However, its role in regulation of GH secretion is not yet clear. Some evidence indicates that circulating concentrations of GH and/or IGF-I could influence ghrelin levels. The pathophysiology of ghrelin secretion in acromegaly (specially aftar an oral glucose tolerance test (OGTT) is unclear.<p class="...

Introduction: Aging is associated with a decrease in muscle and bone mass, and a gain in fat mass. Similar changes are more pronounced in hypercortisolism. We previously demonstrated that high 8 PM salivary cortisol is independently associated with increased prevalence of radiologic vertebral fractures. We wanted to determine whether salivary cortisol circadian rhythm played also a role on body composition.Material and Methods: Cross-sectional study incl...

We herein describe a 55-year-old woman who showed a dramatic improvement in glucose control following treatment for co-existing acromegaly and Cushing’s syndrome. The co-occurrence of acromegaly and Cushing’s syndrome in one individual is extremely rare. This patient was diagnosed as having diabetes mellitus 7 years ago. Afterwards, in spite of insulin therapy, her hyperglycemia could not be well controlled. Endocrinological and radiological examinations revealed sub...

Introduction: Bariatric surgery is an effective therapy for patients with type 2 diabetes mellitus (T2D). Many mechanisms have been proposed for its metabolic benefits, such as caloric restriction, weight loss, increased secretion of gut hormones like glucagon-like peptide 1 (GLP-1) and 2 (GLP-2), bile acid diversion, decrease of pancreatic and hepatic fat deposits and changes in gut microbiome.Aims: Evaluate changes after surgery in gut microbiome profi...

Introduction: Visceral adipose tissue (VAT) is the key target tissue of glucocorticoids (GC) during active Cushing Syndrome (CS) and a metabolic tissue associated to insulin-resistance and an increased cardiometabolic risk. Till date there are no data regarding gene expression in VAT in CS and only few data about the mRNA in subcutaneous one. The aim of this study was to study the visceral VAT tissue transcriptional changes in ACTH-independent CS.Methods...